Product Details
SilybinCAS#22888-70-6
Silybin, also referred to as silibinin, is the maleic-anhydride.html">main bioactive component of the silymarin complex (approximately 70–80%), composed of a blend of silybin A and silybin B. Pharmacological studies have revealed that silybin exhibits diverse biological effects, such as strong antioxidant, anti‑inflammatory, anticancer, antidiabetic, hepatoprotective, neuroprotective, antiviral, antimicrobial and immunosuppressive functions.
Parameters
| Item | Value |
| Melting point | 164-174°C |
| alpha | D20 +11° (c = 0.25 in acetone + alcohol) |
| Boiling point | 793.0±60.0 °C(Predicted) |
| density | 1.527±0.06 g/cm3(Predicted) |
| storage temp. | -20°C |
| solubility | Acetone (Sparingly), DMSO, Methano (Sparingly) |
| form | Solid |
| pka | pKa 6.42±0.04 (Uncertain) |
| color | Pale Yellow |
| Water Solubility | 54mg/L(24.99 ºC) |
| Merck | 13,8607 |
| Stability: | Stable. Incompatible with strong oxidizing agents, strong bases. |
| LogP | 4.232 (est) |
| CAS DataBase Reference | 22888-70-6(CAS DataBase Reference) |
Safety Information
| Item | Value |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 26-37/39-24/25-22-36 |
| RIDADR | 3172 |
| WGK Germany | 3 |
| RTECS | DJ2981770 |
| HS Code | 29329990 |
| Toxicity | LD50 intravenous in mouse: 1056mg/kg |
Product Application of Silybin CAS#22888-70-6
Silibinin has been applied:
• To investigate its influence on the gene expression of various proteins related to chromatin regulation in prostate cancer via real‑time polymerase chain reaction (RT‑PCR)
• To evaluate its impact on cell growth in PDGF‑stimulated human tenon’s fibroblasts (HTFs) by detecting PCNA expression and using the WST‑1 assay
• To analyze its effects on stromelysine 1 (STM1) gene expression, acetyl hexosamines and collagen synthesis during skin wound repair
• To explore its inhibitory action on Escherichia coli ATP synthase
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