Product Details
Step A: In a reaction vessel equipped with a stirrer, thermometer, reflux condenser and dropping funnel, add 0.16 mol of cerium chloride, 0.19 mol of 4‑hydroxy‑3‑methoxyphenmaleic-anhydride.html">material/ethanol.html">ethyl alcohol solution and 400–500 mL of potassium chloride solution. Maintain stirring speed at 160–190 rpm, heat the mixture to 60–65 °C, then slowly add 0.13 mol of 2‑chloro‑6‑nitrobenzoic acid solution and 200 mL of potassium bisulfite solution. Increase stirring speed to 260–310 rpm and reflux for 5–7 hours.
Step B: Cool the solution to 15–19 °C to precipitate solids. Filter the mixture, add 150–180 mL of diammonium hydrogen citrate solution to the filtrate, concentrate under reduced pressure and collect the precipitated solid. After drying, washing with brine and pyridine solution, and recrystallization in ethyl acetate, pure crystalline 2‑amino‑6‑chlorobenzoic acid (C7H6ClNO2) is obtained.
2-Amino-6-chlorobenzoic acid Chemical Properties
| Parameter | Value |
| Melting point | 158-160 °C (lit.) |
| Boiling point | 250°C (rough estimate) |
| density | 1.3246 (rough estimate) |
| refractive index | 1.5560 (estimate) |
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| pka | 0.97±0.10(Predicted) |
| form | Crystalline Powder |
| color | Light yellow to beige |
| Water Solubility | Very soluble in water. Soluble in methanol . |
| BRN | 2804041 |
| Major Application | peptide synthesis |
| InChI | InChI=1S/C7H6ClNO2/c8-4-2-1-3-5(9)6(4)7(10)11/h1-3H,9H2,(H,10,11) |
| InChIKey | SZCPTRGBOVXVCA-UHFFFAOYSA-N |
| SMILES | C(O)(=O)C1=C(Cl)C=CC=C1N |
| CAS DataBase Reference | 2148-56-3(CAS DataBase Reference) |
| NIST Chemistry Reference | 2-Amino-6-chlorobenzoic acid(2148-56-3) |
Safety Information
| Item | Value |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 26-36-37/39 |
| WGK Germany | 3 |
| Hazard Note | Irritant |
| HS Code | 29224999 |
| Storage Class | 11 - Combustible Solids |
| Hazard Classifications | Eye Irrit. 2; Skin Irrit. 2; STOT SE 3 |
Product Application Of 2-Amino-6-chlorobenzoic acid CAS#2148-56-3
Tricyclohexyltin 2‑amino‑6‑chlorobenzoate can be synthesized through the reaction between tricyclohexyltin hydroxide and 2‑amino‑6‑chlorobenzoic acid.
Factory and Equipment Show
Fast delivery time: Inventory 2-3 working days; New production 7-10 working days
