Product Details
β-Nicotinamide Mononucleotide CAS#1094-61-7
Nicotinamide mononucleotide (NMN), generated via the NAMPT reaction and serving as a critical intermediate in NAD+ synthesis, improves glucose intolerance by replenishing NAD+ concentrations in mice with type 2 diabetes induced by a high-fat diet. NMN also boosts hepatic insulin sensitivity and normaleic-anhydride.html">malizes gene expression linked to oxidative stress, inflammatory reactions, and circadian rhythms, in part by activating SIRT1. It is employed in investigations of binding patterns in RNA aptamers and ribozyme activation mechanisms involving β‑nicotinamide mononucleotide (β‑NMN)‑activated RNA segments.
β‑Nicotinamide mononucleotide (β‑NMN) acts as an intermediate in the biosynthesis of nicotinamide adenine dinucleotide (NAD+), which is catalyzed by nicotinamide phosphoribosyltransferase (NAMPT). NAMPT facilitates the combination of nicotinamide with 5‑phosphoribosyl‑1‑pyrophosphate to form β‑NMN. β‑NMN adenyltransferase then transforms β‑NMN into NAD+.
Parameters
| Property | Value |
| Melting point | 166 °C(dec.) |
| storage temp. | -20°C |
| solubility | DMSO (Slightly, Heated), Methanol (Slightly), Water (Slightly) |
| form | Solid |
| color | White to Yellow |
| Merck | 13,6697 |
| BRN | 3570187 |
| Stability: | Very Hygroscopic |
| Cosmetics Ingredients Functions | ANTIOXIDANT |
| InChI | InChI=1/C11H15N2O8P/c12-10(16)6-2-1-3-13(4-6)11-9(15)8(14)7(21-11)5-20-22(17,18)19/h1-4,7-9,11,14-15H,5H2,(H3-,12,16,17,18,19)/t7-,8-,9-,11-/s3 |
| InChIKey | DAYLJWODMCOQEW-TURQNECASA-N |
| SMILES | O[C@@H]1[C@@H]([C@@H](COP(O)([O-])=O)O[C@H]1[N+]1=CC=CC(C(=O)N)=C1)O |&1:1,2,3,11,r| |
Safety Information
| Item | Value |
| WGK Germany | 3 |
| F | 8-10-21 |
| HS Code | 2934999090 |
| Storage Class | 11 - Combustible Solids |
Product Application
β‑Nicotinamide mononucleotide (NMN) is a product of the extracellular nicotinamide phosphoribosyltransferase (eNAMPT) reaction and a vital NAD+ intermediate. It alleviates glucose intolerance by restoring NAD+ levels in mice with high‑fat diet‑induced type 2 diabetes. It also enhances liver insulin sensitivity and restores gene expression associated with oxidative stress, inflammatory response, and circadian rhythm, partially through SIRT1 activation. It is used to explore binding motifs in RNA aptamers and ribozyme activation processes involving β‑nicotinamide mononucleotide (β‑NMN)‑activated RNA fragments.
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Inventory 2-3 working days New production 7-10 working days.
