Product Details
Ethyl acetate (systemaleic-anhydride.html">matically ethyl ethanoate, commonly shortened to EtOAc or EA) is an organic compound with the molecular formula CH3COOCH2CH3. This clear liquid features a distinct sweet scent reminiscent of pear drops. It is widely used in adhesives, nail polish removers, decaffeination of tea and coffee, and as an additive in cigarettes. Ethyl acetate is the ester formed from ethanol and acetic acid and is produced industrially on a large scale for use as a versatile solvent. In 1985, the combined annual output in Japan, North America, and Europe reached approximately 400,000 tons. By 2004, global production was estimated at 1.3 million tons.
Parameters
| Property | Value |
| Melting point | −84 °C(lit.) |
| Boiling point | 76.5-77.5 °C(lit.) |
| density | 0.902 g/mL at 25 °C(lit.) |
| vapor density | 3 (20 °C, vs air) |
| vapor pressure | 73 mm Hg ( 20 °C) |
| refractive index | n20/D 1.3720(lit.) |
| FEMA | 2414 | ETHYL ACETATE |
| Fp | 26 °F |
| storage temp. | Store at +2°C to +25°C. |
| solubility | Miscible with ethanol, acetone, diethyl ether and benzene. |
| form | Liquid |
| pka | 16-18(at 25℃) |
| color | APHA: ≤10 |
| Specific Gravity | 0.902 (20/20℃) |
| Relative polarity | 0.228 |
| Odor | Pleasant fruity odor detectable at 7 to 50 ppm (mean = 18 ppm) |
| Odor Threshold | 0.87ppm |
| Odor Type | ethereal |
| biological source | synthetic |
| explosive limit | 2.2-11.5%, 38°F |
| Water Solubility | 80 g/L (20 ºC) |
| λmax | λ: 256 nm Amax: ≤1.00 λ: 275 nm Amax: ≤0.05 λ: 300 nm Amax: ≤0.03 λ: 325-400 nm Amax: ≤0.005 |
| Merck | 14,3757 |
| JECFA Number | 27 |
| BRN | 506104 |
| Henry's Law Constant | 0.39 at 5.00 °C, 0.58 at 10.00 °C, 0.85 at 15.00 °C, 1.17 at 20.00 °C, 1.58 at 25.00 °C (column stripping-UV, Kutsuna et al., 2005) |
| Exposure limits | TLV-TWA 400 ppm (～1400 mg/m3) (ACGIH, MSHA, and OSHA); IDLH 10,000 ppm (NIOSH). |
| Dielectric constant | 23.0（Ambient） |
| Stability: | Stable. Incompatible with various plastics, strong oxidizing agents. Highly flammable. Vapour/air mixtures explosive. May be moisture sensitive. |
| Cosmetics Ingredients Functions | SOLVENT PERFUMING |
| Cosmetic Ingredient Review (CIR) | Ethyl acetate (141-78-6) |
| InChI | 1S/C4H8O2/c1-3-6-4(2)5/h3H2,1-2H3 |
| InChIKey | XEKOWRVHYACXOJ-UHFFFAOYSA-N |
| SMILES | CCOC(C)=O |
| LogP | 0.68-0.73 at 20-25℃ |
| Surface tension | 23.93mN/m at 293.15K |
| CAS DataBase Reference | 141-78-6(CAS DataBase Reference) |
| NIST Chemistry Reference | Ethyl acetate(141-78-6) |
| EPA Substance Registry System | Ethyl acetate (141-78-6) |
Safety Information
| Item | Details |
| Hazard Codes | F,Xi,Xn,T |
| Risk Statements | 11-36-66-67-20/21/22-10-39/23/24/25-23/24/25-68/20/21/22 |
| Safety Statements | 16-26-33-36/37-45-7-25 |
| RIDADR | UN 1173 3/PG 2 |
| OEB | A |
| OEL | TWA: 400 ppm (1400 mg/m3) |
| WGK Germany | 1 |
| RTECS | AH5425000 |
| F | 1 |
| Autoignition Temperature | 427 °C |
| TSCA | TSCA listed |
| HS Code | 2915 31 00 |
| HazardClass | 3 |
| PackingGroup | II |
| Storage Class | 3 - Flammable liquids |
| Hazard Classifications | Eye Irrit. 2 Flam. Liq. 2 STOT SE 3 |
| Hazardous Substances Data | 141-78-6(Hazardous Substances Data) |
| Toxicity | LD50 orally in rats: 11.3 ml/kg (Smyth) |
| IDLA | 2,000 ppm [10% LEL] |
Product Application
In pharmaceutical preparations, ethyl acetate serves mainly as a solvent, though it is also employed as a flavoring agent. As a solvent, it appears in topical solutions, gels, and edible printing inks for tablets. It has been found to boost the solubility of chlortalidone and modify polymorphic crystal structures of piroxicam pivalate, mefenamic acid, and fluconazole. It is used in microsphere formulations and in manufacturing liposomal amphotericin B dry powder inhalers. Studies have also explored its role as a chemical penetration enhancer for transdermal iontophoresis of insulin.
In food applications, ethyl acetate is primarily used as a flavoring agent. It is also included in artificial fruit essences and acts as an extraction solvent during food processing.
Factory and Equipment Show
Fast delivery time
Inventory 2-3 working days New production 7-10 working days.
